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Aptamer Group partner with BaseCure Therapeutics to develop new targeted gene therapies

31 JAN, 2023

Optimer binders to specific cell types will enable targeted delivery
Optimer delivery vehicles could increase uptake of the siRNA therapy into the target cells Aptamer Group plc, the developer of novel Optimer® binders to enable innovation in the life sciences industry, today announces a new partnership with BaseCure Therapeutics for the development of Optimer-targeted gene therapies.

BaseCure Therapeutics is a pre-clinical stage biotech company dedicated to the discovery and development of innovative siRNA-based medicines. Aptamer is working with BaseCure Therapeutics to identify Optimer binders that identify specific cell types that might be developed as potential delivery vehicles for siRNA uptake into target cells and tissues.

siRNA therapeutics form the largest portion of the rapidly developing gene therapy market. While these therapies have shown excellent potential in the clinic and the FDA approval of four siRNA treatments, there remains a major challenge of targeting the therapeutic to the desired cell or organ within the body and further cellular internalisation to allow its gene silencing function.

Optimer binders are oligonucleotide affinity ligands that can be used as antibody alternatives. Selected wholly in vitro Optimers offer the potential to tune target affinity and half-life, and allow for site-directed payload conjugation for controlled Optimer: therapeutic ratios. Optimer binders can be combined with various payloads, from small molecule drugs to gene therapies, such as BaseCure Therapeutics’ siRNA. The ability to achieve Optimer-directed targeted delivery would offer exciting new therapeutic opportunities of siRNA-mediated gene knockdown in these target cells and tissues.

Source: https://aptamergroup.com/aptamer-partner-with-basecure-for-targeted-gene-therapies/


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