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The Pfizer–BioNTech COVID-19 vaccine was the first mRNA vaccine approved by a medicines regulator, followed by the Moderna COVID-19 vaccine, and others. The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Our medicines use RNA interference (RNAi) to “silence” or turn off the production of specific genes that cause disease or that contribute to disease. RNAi is a natural biological process that regulates gene expression by “interfering” with messenger RNA (mRNA), which carries DNA's instructions for making new proteins.
Examples of therapeutics include drug therapy, medical devices, nutrition therapy and stem-cell therapies. Therapeutics can be used in patients with active disease – to treat the disease itself or its signs and symptoms – in preventive medicine, or as palliative care.