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Oligonucleotides containing CpG motifs and immunomodulatory oligonucleotides (IMO) containing a synthetic immunostimulatory dinucleotide and a novel DNA structure have been suggested to have potential for the treatment of various human diseases. A medicinal composition comprising an oligonucleotide delivery complex formed from an immunostimulatory oligonucleotide containing at least one unmethylated CpG dinucleotide and a sterol, a lipid, or a target cell specific binding agent. The oligonucleotide can be stabilised or a phosphodiester.